Sancho Lab

Pancreatic plasticity and regeneration

Key publications

Cujba, A. M., Alvarez-Fallas, M. E., Pedraza-Arevalo, S., Laddach, A., Shepherd, M. H., Hattersley, A. T., Watt, F. M., & Sancho, R. An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function. Cell reports 2022 Mar, 38(9), 110425. https://doi.org/10.1016/j.celrep.2022.110425

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Alvarez Fallas, M. E., Pedraza-Arevalo, S., Cujba, A.-M., Manea, T., Lambert, C., Morrugares, R., & Sancho, R. Stem/progenitor cells in normal physiology and disease of the pancreas. Molecular and Cellular Endocrinology 2021 Sep, 538, 111459. https://doi.org/https://doi.org/10.1016/j.mce.2021.111459

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Gribben C, Lambert C, Messal HA, Hubber EL, Rackham C, Evans I, Heimberg H, Jones P, Sancho R, Behrens A. Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas. Cell Stem Cell 2021 Sep; https://doi.org/10.1016/j.stem.2021.08.003.

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Goldman O, Puchinsky D, Durlacher K, Sancho R, Ludwig B, Kugelmeier P, Heller C, Kunicher N, Bornstein SR, Treves AJ. Lung Based Engineered Micro-Pancreas Sustains Human Beta Cell Survival and Functionality. Horm Metab Res. 2019 Dec;51(12):805-811. doi: 10.1055/a-1041-3305. Epub 2019 Dec 11. PubMed PMID: 31826275.

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Segal JM, Kent D, Wesche DJ, Ng SS, Serra M, Oulès B, Kar G, Emerton G, Blackford SJI, Darmanis S, Miquel R, Luong TV, Yamamoto R, Bonham A, Jassem W, Heaton N, Vigilante A, King A, Sancho R, Teichmann S, Quake SR, Nakauchi H, Rashid ST. Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun. 2019 Jul 26;10(1):3350. doi: 10.1038/s41467-019-11266-x. PubMed PMID: 31350390; PubMed Central PMCID: PMC6659636.

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Ruiz EJ, Diefenbacher ME, Nelson JK, Sancho R, Pucci F, Chakraborty A, Moreno P, Annibaldi A, Liccardi G, Encheva V, Mitter R, Rosenfeldt M, Snijders AP, Meier P, Calzado MA, Behrens A. LUBAC determines chemotherapy resistance in squamous cell lung cancer. J Exp Med. 2019 Feb 4;216(2):450-465. doi: 10.1084/jem.20180742. Epub 2019 Jan 14. PubMed PMID: 30642944; PubMed Central PMCID: PMC6363428.

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Demcollari TI, Cujba AM, Sancho R. Phenotypic plasticity in the pancreas: new triggers, new players. Curr Opin Cell Biol. 2017 Dec;49:38-46. doi: 10.1016/j.ceb.2017.11.014. Epub 2017 Dec 8. Review. PubMed PMID: 29227863; PubMed Central PMCID: PMC6277812.

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Ferreira RMM, Sancho R, Messal HA, Nye E, Spencer-Dene B, Stone RK, Stamp G, Rosewell I, Quaglia A, Behrens A. Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression. Cell Rep. 2017 Oct 24;21(4):966-978. doi: 10.1016/j.celrep.2017.09.093. PubMed PMID: 29069604; PubMed Central PMCID: PMC5668631.

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Cremona CA, Sancho R, Diefenbacher ME, Behrens A. Fbw7 and its counteracting forces in stem cells and cancer: Oncoproteins in the balance. Semin Cancer Biol. 2016 Feb;36:52-61. doi: 10.1016/j.semcancer.2015.09.006. Epub 2015 Sep 26. Review. PubMed PMID: 26410034.

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Sancho R, Cremona CA, Behrens A. Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease. EMBO Rep. 2015 May;16(5):571-81. doi: 10.15252/embr.201540188. Epub 2015 Apr 8. Review. PubMed PMID: 25855643; PubMed Central PMCID: PMC4428041.

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Sancho R, Gruber R, Gu G, Behrens A. Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells. Cell Stem Cell. 2014 Aug 7;15(2):139-53. doi:  10.1016/j.stem.2014.06.019. PubMed PMID: 25105579; PubMed Central PMCID: PMC4136739.

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